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  <xsd:import namespace="http://www.xbrl.org/dtr/type/2024-01-31" schemaLocation="https://www.xbrl.org/dtr/type/2024-01-31/types.xsd" />
  <xsd:import namespace="http://www.xbrl.org/2009/role/negated" schemaLocation="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd" />
  <xsd:import namespace="http://www.xbrl.org/2003/instance" schemaLocation="http://www.xbrl.org/2003/xbrl-instance-2003-12-31.xsd" />
  <xsd:import namespace="http://xbrl.org/2005/xbrldt" schemaLocation="http://www.xbrl.org/2005/xbrldt-2005.xsd" />
  <xsd:import namespace="http://fasb.org/srt/2025" schemaLocation="https://xbrl.fasb.org/srt/2025/elts/srt-2025.xsd" />
  <xsd:import namespace="https://xbrl.ifrs.org/taxonomy/2025-03-27/ifrs-full" schemaLocation="https://xbrl.ifrs.org/taxonomy/2025-03-27/full_ifrs/full_ifrs-cor_2025-03-27.xsd" />
  <xsd:import namespace="http://xbrl.sec.gov/currency/2025" schemaLocation="https://xbrl.sec.gov/currency/2025/currency-2025.xsd" />
  <xsd:element name="DocumentAndEntityInformationAbstract" id="prqr_DocumentAndEntityInformationAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="DisclosureOfOtherIncomeTableTextBlockExplanatory" id="prqr_DisclosureOfOtherIncomeTableTextBlockExplanatory" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="IfrsRevenueFromGrants" id="prqr_IfrsRevenueFromGrants" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element name="IfrsOtherIncomeAbstract" id="prqr_IfrsOtherIncomeAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="GeneralInformationAbstract" id="prqr_GeneralInformationAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="ProqrTherapeuticsHoldingB.v.Member" id="prqr_ProqrTherapeuticsHoldingB.v.Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="ProqrTherapeuticsIB.v.Member" id="prqr_ProqrTherapeuticsIB.v.Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="ProqrTherapeuticsIiB.v.Member" id="prqr_ProqrTherapeuticsIiB.v.Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="ProqrTherapeuticsIiiB.v.Member" id="prqr_ProqrTherapeuticsIiiB.v.Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="ProqrTherapeuticsIvB.v.Member" id="prqr_ProqrTherapeuticsIvB.v.Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="ProqrTherapeuticsViB.v.Member" id="prqr_ProqrTherapeuticsViB.v.Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="ProqrTherapeuticsViiB.v.Member" id="prqr_ProqrTherapeuticsViiB.v.Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="ProqrTherapeuticsViiiB.v.Member" id="prqr_ProqrTherapeuticsViiiB.v.Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="ProqrTherapeuticsIxB.v.Member" id="prqr_ProqrTherapeuticsIxB.v.Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="ProqrTherapeuticsIInc.Member" id="prqr_ProqrTherapeuticsIInc.Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="DisclosureOfGeneralInformationExplanatory" id="prqr_DisclosureOfGeneralInformationExplanatory" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="MaturityGroupingsAxis" id="prqr_MaturityGroupingsAxis" type="xbrli:stringItemType" substitutionGroup="xbrldt:dimensionItem" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="MaturityGroupingsDomain" id="prqr_MaturityGroupingsDomain" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="AuthorizedShareCapitalValue" id="prqr_AuthorizedShareCapitalValue" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit" xbrli:periodType="instant" />
  <xsd:element name="IfrsSubsidiarySaleOfStockAxis" id="prqr_IfrsSubsidiarySaleOfStockAxis" type="xbrli:stringItemType" substitutionGroup="xbrldt:dimensionItem" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="IfrsSaleOfStockNameOfTransactionDomain" id="prqr_IfrsSaleOfStockNameOfTransactionDomain" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="IfrsNumberOfReportableSegments" id="prqr_IfrsNumberOfReportableSegments" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="IfrsScenarioAxis" id="prqr_IfrsScenarioAxis" type="xbrli:stringItemType" substitutionGroup="xbrldt:dimensionItem" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="IfrsScenarioUnspecifiedDomain" id="prqr_IfrsScenarioUnspecifiedDomain" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="OtherIncomeTable" id="prqr_OtherIncomeTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="OtherIncomeLineItems" id="prqr_OtherIncomeLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="IfrsStockIssuedDuringPeriodSharesNewIssues" id="prqr_IfrsStockIssuedDuringPeriodSharesNewIssues" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="InnovationCreditMember" id="prqr_InnovationCreditMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="SharesOptionsLapsed" id="prqr_SharesOptionsLapsed" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="IfrsAccountingPoliciesAbstract" id="prqr_IfrsAccountingPoliciesAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="ConditionalWaiverOfDebtTotal" id="prqr_ConditionalWaiverOfDebtTotal" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="debit" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="IfrsSaleOfStockPricePerShare" id="prqr_IfrsSaleOfStockPricePerShare" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="IfrsSubsequentEventsAxis" id="prqr_IfrsSubsequentEventsAxis" type="xbrli:stringItemType" substitutionGroup="xbrldt:dimensionItem" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="IfrsSubsequentEventsDomain" id="prqr_IfrsSubsequentEventsDomain" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="AreaOfPropertyUnderLease" id="prqr_AreaOfPropertyUnderLease" type="dtr-types:areaItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" />
  <xsd:element name="IfrsResearchAndDevelopmentExpenseMember" id="prqr_IfrsResearchAndDevelopmentExpenseMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="IfrsSellingGeneralAndAdministrativeExpensesMember" id="prqr_IfrsSellingGeneralAndAdministrativeExpensesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="OfficeAndLaboratoryFacilityMember" id="prqr_OfficeAndLaboratoryFacilityMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="LeidenNetherlandsMember" id="prqr_LeidenNetherlandsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="PhoenicisTherapeuticsIncMember" id="prqr_PhoenicisTherapeuticsIncMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="TreasurySharesTransferred" id="prqr_TreasurySharesTransferred" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="IfrsStockIssuedDuringPeriodSharesStockOptionsExercised" id="prqr_IfrsStockIssuedDuringPeriodSharesStockOptionsExercised" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="AdjustmentsForOtherIncome" id="prqr_AdjustmentsForOtherIncome" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:balance="credit" xbrli:periodType="duration" />
  <xsd:element name="ProqrTherapeuticsVB.v.Member" id="prqr_ProqrTherapeuticsVB.v.Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="YarrowBiotechnologyMember" id="prqr_YarrowBiotechnologyMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="IfrsCounterpartyNameAxis" id="prqr_IfrsCounterpartyNameAxis" type="xbrli:stringItemType" substitutionGroup="xbrldt:dimensionItem" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="IfrsRepurchaseAgreementCounterpartyNameDomain" id="prqr_IfrsRepurchaseAgreementCounterpartyNameDomain" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="IfrsSaleOfStockAxis" id="prqr_IfrsSaleOfStockAxis" type="xbrli:stringItemType" substitutionGroup="xbrldt:dimensionItem" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="IfrsSaleOfStockDomain" id="prqr_IfrsSaleOfStockDomain" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="EliLillyAndCompanyMember" id="prqr_EliLillyAndCompanyMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="IfrsBalanceSheetLocationAxis" id="prqr_IfrsBalanceSheetLocationAxis" type="xbrli:stringItemType" substitutionGroup="xbrldt:dimensionItem" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="IfrsBalanceSheetLocationDomain" id="prqr_IfrsBalanceSheetLocationDomain" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="ProportionOfOwnershipInterest" id="prqr_ProportionOfOwnershipInterest" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" />
  <xsd:element name="IfrsStatementScenarioAxis" id="prqr_IfrsStatementScenarioAxis" type="xbrli:stringItemType" substitutionGroup="xbrldt:dimensionItem" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="ScenarioDomain" id="prqr_ScenarioDomain" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" abstract="true" nillable="true" xbrli:periodType="duration" />
  <xsd:element name="InvestmentsInFinancialAssetsAbstract" id="prqr_InvestmentsInFinancialAssetsAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="DisclosureOfInvestmentInFinancialAssetAndGainOnDisposalOfAssociateTable" id="prqr_DisclosureOfInvestmentInFinancialAssetAndGainOnDisposalOfAssociateTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="DisclosureOfInvestmentInFinancialAssetAndGainOnDisposalOfAssociateLineItems" id="prqr_DisclosureOfInvestmentInFinancialAssetAndGainOnDisposalOfAssociateLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="DeferredIncomeAbstract" id="prqr_DeferredIncomeAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ScheduleOfDeferredIncomeTableTextBlock" id="prqr_ScheduleOfDeferredIncomeTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="WarrantsEconomicLifetime" id="prqr_WarrantsEconomicLifetime" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="DiscountOnIssueOfShares" id="prqr_DiscountOnIssueOfShares" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="IfrsCollaborativeArrangementAndArrangementOtherThanCollaborativeAxis" id="prqr_IfrsCollaborativeArrangementAndArrangementOtherThanCollaborativeAxis" type="xbrli:stringItemType" substitutionGroup="xbrldt:dimensionItem" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="IfrsCollaborativeArrangementAndArrangementOtherThanCollaborativeDomain" id="prqr_IfrsCollaborativeArrangementAndArrangementOtherThanCollaborativeDomain" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="AdditionalConsiderationToBeReceivedIfCounterpartyExercisesOptionToExpandPartnership" id="prqr_AdditionalConsiderationToBeReceivedIfCounterpartyExercisesOptionToExpandPartnership" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="OtherCurrentLiabilitiesAbstract" id="prqr_OtherCurrentLiabilitiesAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="NumberOfPerformanceObligationsInCollaborationAgreement" id="prqr_NumberOfPerformanceObligationsInCollaborationAgreement" type="xbrli:integerItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="IfrsClassesOfWarrantsOrRightsAxisAxis" id="prqr_IfrsClassesOfWarrantsOrRightsAxisAxis" type="xbrli:stringItemType" substitutionGroup="xbrldt:dimensionItem" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ClassesOfWarrantsOrRightsDomain" id="prqr_ClassesOfWarrantsOrRightsDomain" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="PontifaxAndKreosWarrantsMember" id="prqr_PontifaxAndKreosWarrantsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="LeaseTerm" id="prqr_LeaseTerm" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="LeaseExtensionTerm" id="prqr_LeaseExtensionTerm" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="LeaseCurrentExtensionPeriodUnderOption" id="prqr_LeaseCurrentExtensionPeriodUnderOption" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="ShelfRegistrationStatement2024Member" id="prqr_ShelfRegistrationStatement2024Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="MaximumOfferingPriceInShelfRegistrationStatement" id="prqr_MaximumOfferingPriceInShelfRegistrationStatement" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="AtMarketOfferingsWithCantorFitzgeraldAndCoUnderShelfRegistrationStatementMember" id="prqr_AtMarketOfferingsWithCantorFitzgeraldAndCoUnderShelfRegistrationStatementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="PercentageOfCommissionPayableForGrossProceedsFromSalesAgreement" id="prqr_PercentageOfCommissionPayableForGrossProceedsFromSalesAgreement" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="RettSyndromeResearchTrustMember" id="prqr_RettSyndromeResearchTrustMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="ResearchAndDevelopmentCostsAbstract" id="prqr_ResearchAndDevelopmentCostsAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="October2024UnderwrittenPublicOfferingMember" id="prqr_October2024UnderwrittenPublicOfferingMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="UnderwritersOptionInConnectionToOctober2024UnderwrittenPublicOfferingMember" id="prqr_UnderwritersOptionInConnectionToOctober2024UnderwrittenPublicOfferingMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="DurationOfUnderwritersOption" id="prqr_DurationOfUnderwritersOption" type="xbrli:durationItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="NumberOfSharesCallableForOptionsIssued" id="prqr_NumberOfSharesCallableForOptionsIssued" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" />
  <xsd:element name="NetProceedsFromIssuingShares" id="prqr_NetProceedsFromIssuingShares" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="debit" />
  <xsd:element name="PurchasePriceCapSharePurchaseAgreement" id="prqr_PurchasePriceCapSharePurchaseAgreement" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="SharePurchaseAgreementWithEliLillyAndCompanyMember" id="prqr_SharePurchaseAgreementWithEliLillyAndCompanyMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="MilestonePaymentsMember" id="prqr_MilestonePaymentsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="true" />
  <xsd:element name="MaximumGrantReceivableForInitialPhaseOfProject" id="prqr_MaximumGrantReceivableForInitialPhaseOfProject" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="MaximumGrantReceivableForAdditionalPhaseOfProject" id="prqr_MaximumGrantReceivableForAdditionalPhaseOfProject" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
  <xsd:element name="CurrentBorrowingsExcludingAccruedInterest" id="prqr_CurrentBorrowingsExcludingAccruedInterest" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="credit" />
  <xsd:element name="ValueOfMilestonesReachedDuringPeriod" id="prqr_ValueOfMilestonesReachedDuringPeriod" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" xbrli:balance="credit" />
  <xsd:element name="DisclosureOfTradeAndOtherReceivablesTableTextBlock" id="prqr_DisclosureOfTradeAndOtherReceivablesTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="duration" abstract="false" />
  <xsd:element name="CurrentReceivablesFromCollaborationAgreements" id="prqr_CurrentReceivablesFromCollaborationAgreements" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" nillable="true" xbrli:periodType="instant" abstract="false" xbrli:balance="debit" />
</xsd:schema>
