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SC 13G/A

 

 

UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

WASHINGTON, D.C. 20549

 

 

SCHEDULE 13G

Under the Securities Exchange Act of 1934*

(Amendment No. 2)

 

 

ProQR Therapeutics N.V.

 

(Name of Issuer)

Ordinary Shares, nominal value €0.04 per share

 

(Title of Class of Securities)

N71542109

 

(CUSIP Number)

December 31, 2018

 

(Date of Event Which Requires Filing of this Statement)

 

 

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

☐ Rule 13d-1(b)

☒ Rule 13d-1(c)

☐ Rule 13d-1(d)

 

*

The remainder of this cover page shall be filled out for a reporting person’s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed to be “filed” for the purpose of Section 18 of the Securities Exchange Act of 1934 (“Act”) or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).

 

 

 

CUSIP No. N71542109   13G           

 

  1   

NAMES OF REPORTING PERSONS

I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

 

Invus Public Equities, L.P.

  2  

CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

(a)  ☐        (b)  ☐

 

  3  

SEC USE ONLY

 

  4  

CITIZENSHIP OR PLACE OF ORGANIZATION

 

Bermuda    

NUMBER OF

SHARES

BENEFICIALLY

OWNED BY

EACH

REPORTING

PERSON

WITH

    5    

SOLE VOTING POWER

 

1,400,000    

   6   

SHARED VOTING POWER

 

0    

   7   

SOLE DISPOSITIVE POWER

 

1,400,000    

   8   

SHARED DISPOSITIVE POWER

 

0    

  9  

AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

 

1,400,000    

10  

CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS)

 

☐    

11  

PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

 

3.62%    

12  

TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)

 

PN    

CUSIP No. N71542109   13G           

 

  1   

NAMES OF REPORTING PERSONS

I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

 

Invus Public Equities Advisors, LLC

  2  

CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

(a)  ☐        (b)  ☐

 

  3  

SEC USE ONLY

 

  4  

CITIZENSHIP OR PLACE OF ORGANIZATION

 

Delaware    

NUMBER OF

SHARES

BENEFICIALLY

OWNED BY

EACH

REPORTING

PERSON

WITH

    5    

SOLE VOTING POWER

 

1,400,000    

   6   

SHARED VOTING POWER

 

0    

   7   

SOLE DISPOSITIVE POWER

 

1,400,000    

   8   

SHARED DISPOSITIVE POWER

 

0    

  9  

AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

 

1,400,000    

10  

CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS)

 

☐    

11  

PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

 

3.62%    

12  

TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)

 

OO    

CUSIP No. N71542109   13G           

 

  1   

NAMES OF REPORTING PERSONS

I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

 

Artal Treasury Limited

  2  

CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

(a)  ☐        (b)  ☐

 

  3  

SEC USE ONLY

 

  4  

CITIZENSHIP OR PLACE OF ORGANIZATION

 

Guernsey    

NUMBER OF

SHARES

BENEFICIALLY

OWNED BY

EACH

REPORTING

PERSON

WITH

    5    

SOLE VOTING POWER

 

1,400,000    

   6   

SHARED VOTING POWER

 

0    

   7   

SOLE DISPOSITIVE POWER

 

1,400,000    

   8   

SHARED DISPOSITIVE POWER

 

0    

  9  

AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

 

1,400,000    

10  

CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS)

 

☐    

11  

PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

 

3.62%    

12  

TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)

 

OO    

CUSIP No. N71542109   13G           

 

  1   

NAMES OF REPORTING PERSONS

I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

 

Artal International S.C.A.

  2  

CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

(a)  ☐        (b)  ☐

 

  3  

SEC USE ONLY

 

  4  

CITIZENSHIP OR PLACE OF ORGANIZATION

 

Luxembourg    

NUMBER OF

SHARES

BENEFICIALLY

OWNED BY

EACH

REPORTING

PERSON

WITH

    5    

SOLE VOTING POWER

 

1,400,000    

   6   

SHARED VOTING POWER

 

0    

   7   

SOLE DISPOSITIVE POWER

 

1,400,000    

   8   

SHARED DISPOSITIVE POWER

 

0    

  9  

AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

 

1,400,000    

10  

CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS)

 

☐    

11  

PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

 

3.62%    

12  

TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)

 

OO    

CUSIP No. N71542109   13G           

 

  1   

NAMES OF REPORTING PERSONS

I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

 

Artal International Management S.A.

  2  

CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

(a)  ☐        (b)  ☐

 

  3  

SEC USE ONLY

 

  4  

CITIZENSHIP OR PLACE OF ORGANIZATION

 

Luxembourg    

NUMBER OF

SHARES

BENEFICIALLY

OWNED BY

EACH

REPORTING

PERSON

WITH

    5    

SOLE VOTING POWER

 

1,400,000    

   6   

SHARED VOTING POWER

 

0    

   7   

SOLE DISPOSITIVE POWER

 

1,400,000    

   8   

SHARED DISPOSITIVE POWER

 

0    

  9  

AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

 

1,400,000    

10  

CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS)

 

☐    

11  

PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

 

3.62%    

12  

TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)

 

OO    

CUSIP No. N71542109   13G           

 

  1   

NAMES OF REPORTING PERSONS

I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

 

Artal Group S.A.

  2  

CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

(a)  ☐        (b)  ☐

 

  3  

SEC USE ONLY

 

  4  

CITIZENSHIP OR PLACE OF ORGANIZATION

 

Luxembourg    

NUMBER OF

SHARES

BENEFICIALLY

OWNED BY

EACH

REPORTING

PERSON

WITH

    5    

SOLE VOTING POWER

 

1,400,000    

   6   

SHARED VOTING POWER

 

0    

   7   

SOLE DISPOSITIVE POWER

 

1,400,000    

   8   

SHARED DISPOSITIVE POWER

 

0    

  9  

AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

 

1,400,000    

10  

CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS)

 

☐    

11  

PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

 

3.62%    

12  

TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)

 

OO    

CUSIP No. N71542109   13G           

 

  1   

NAMES OF REPORTING PERSONS

I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

 

Westend S.A.

  2  

CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

(a)  ☐        (b)  ☐

 

  3  

SEC USE ONLY

 

  4  

CITIZENSHIP OR PLACE OF ORGANIZATION

 

Luxembourg    

NUMBER OF

SHARES

BENEFICIALLY

OWNED BY

EACH

REPORTING

PERSON

WITH

    5    

SOLE VOTING POWER

 

1,400,000    

   6   

SHARED VOTING POWER

 

0    

   7   

SOLE DISPOSITIVE POWER

 

1,400,000    

   8   

SHARED DISPOSITIVE POWER

 

0    

  9  

AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

 

1,400,000    

10  

CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS)

 

☐    

11  

PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

 

3.62%    

12  

TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)

 

OO    

CUSIP No. N71542109   13G           

 

  1   

NAMES OF REPORTING PERSONS

I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

 

Stichting Administratiekantoor Westend

  2  

CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

(a)  ☐        (b)  ☐

 

  3  

SEC USE ONLY

 

  4  

CITIZENSHIP OR PLACE OF ORGANIZATION

 

The Netherlands    

NUMBER OF

SHARES

BENEFICIALLY

OWNED BY

EACH

REPORTING

PERSON

WITH

    5    

SOLE VOTING POWER

 

1,400,000    

   6   

SHARED VOTING POWER

 

0    

   7   

SOLE DISPOSITIVE POWER

 

1,400,000    

   8   

SHARED DISPOSITIVE POWER

 

0    

  9  

AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

 

1,400,000    

10  

CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS)

 

☐    

11  

PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

 

3.62%    

12  

TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)

 

OO    

CUSIP No. N71542109   13G           

 

  1   

NAMES OF REPORTING PERSONS

I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)

 

Mr. Pascal Minne

  2  

CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP

(a)  ☐        (b)  ☐

 

  3  

SEC USE ONLY

 

  4  

CITIZENSHIP OR PLACE OF ORGANIZATION

 

Belgium    

NUMBER OF

SHARES

BENEFICIALLY

OWNED BY

EACH

REPORTING

PERSON

WITH

    5    

SOLE VOTING POWER

 

1,400,000    

   6   

SHARED VOTING POWER

 

0    

   7   

SOLE DISPOSITIVE POWER

 

1,400,000    

   8   

SHARED DISPOSITIVE POWER

 

0    

  9  

AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

 

1,400,000    

10  

CHECK IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS)

 

☐    

11  

PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)

 

3.62%    

12  

TYPE OF REPORTING PERSON (SEE INSTRUCTIONS)

 

IN    

Item 1(a).

Name of Issuer:

ProQR Therapeutics N.V. (the “Issuer”)

 

Item 1(b).

Address of Issuer’s Principal Executive Offices:

Zernikedreef 9, 2333 CK Leiden, The Netherlands

 

Item 2(a).

Name of Person Filing:

Item 2(b).

Address of Principal Business Office or, if none, Residence:

Item 2(c).

Citizenship:

(i) Invus Public Equities, L.P. (“Invus Public Equities”)

750 Lexington Avenue, 30th Floor, New York, NY 10022

Citizenship: Bermuda limited partnership

(ii) Invus Public Equities Advisors, LLC (“Invus PE Advisors”)

750 Lexington Avenue, 30th Floor, New York, NY 10022

Citizenship: Delaware limited liability company

(iii) Artal Treasury Limited (“Artal Treasury”)

PO Box 265, Suite 6, Borough House, Rue du Pre, St. Peter Port, Guernsey GY1 3QU

Citizenship: Guernsey company

(iv) Artal International S.C.A. (“Artal International”)

Valley Park, 44, Rue de la Vallée, L-2661, Luxembourg

Citizenship: Luxembourg limited partnership

(v) Artal International Management S.A. (“Artal International Management”)

Valley Park, 44, Rue de la Vallée, L-2661, Luxembourg

Citizenship: Luxembourg société anonyme

(vi) Artal Group S.A. (“Artal Group”)

Valley Park, 44, Rue de la Vallée, L-2661, Luxembourg

Citizenship: Luxembourg société anonyme

(vii) Westend S.A. (“Westend”)

Valley Park, 44, Rue de la Vallée, L-2661, Luxembourg

Citizenship: Luxembourg société anonyme

(viii) Stichting Administratiekantoor Westend (the “Stichting”)

Ijsselburcht 3 NL-6825 BS Arnhem, The Netherlands

Citizenship: Netherlands foundation

(ix) Mr. Pascal Minne

Rue de l’Industrie 44, B-1000, Bruxelles, Belgium

Citizenship: Belgium

The foregoing persons are hereinafter sometimes collectively referred to as the “Reporting Persons.”

Item 2(d).

Title of Class of Securities:

Ordinary Shares, nominal value €0.04 per share (the “Shares”)

 

Item 2(e).

CUSIP Number:

N71542109

 

Item 3.

If This Statement Is Filed Pursuant to Sections 240.13d-1(b) or 240.13d-2(b) or (c), Check Whether the Person Filing Is a(n):

This Item 3 is not applicable.

 

Item 4.

Ownership.

(a) Amount beneficially owned:

As of December 31, 2018, each of the Reporting Persons may be deemed the beneficial owner of 1,400,000 Shares held for the account of Invus Public Equities.

(b) Percent of class:

As of December 31, 2018, each of the Reporting Persons may be deemed the beneficial owner of approximately 3.62% of Shares outstanding. Calculations of the percentage of Shares beneficially owned assume 38,715,563 Shares outstanding as of September 30, 2018 according to the Issuer’s Registration Statement on Form F-3 filed with the Securities and Exchange Commission on November 7, 2018.

(c) Number of shares as to which the person has:

Invus Public Equities, Invus PE Advisors, Artal Treasury, Artal International, Artal International Management, Artal Group, Westend, The Stichting and Mr. Minne:

(i) Sole power to vote or to direct the vote:

1,400,000

(ii) Shared power to vote or to direct the vote:

0

(iii) Sole power to dispose or to direct the disposition of:

1,400,000

(iv) Shared power to dispose or to direct the disposition of:

0

Item 5.

Ownership of Five Percent or Less of a Class.

If this statement is being filed to report the fact that as of the date hereof the reporting person has ceased to be the beneficial owner of more than five percent of the class of securities, check the following ☒.

 

Item 6.

Ownership of More Than Five Percent on Behalf of Another Person.

This Item 6 is not applicable.

 

Item 7.

Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company.

This Item 7 is not applicable.

 

Item 8.

Identification and Classification of Members of the Group.

This Item 8 is not applicable.

 

Item 9.

Notice of Dissolution of Group.

This Item 9 is not applicable.

 

Item 10.

Certification.

Each of the Reporting Persons hereby makes the following certification:

By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the Issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect.

SIGNATURE

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

 

INVUS PUBLIC EQUITIES, L.P.
By: INVUS PUBLIC EQUITIES ADVISORS, LLC, its general partner
By:   /s/ Raymond Debbane
Name:   Raymond Debbane
Title:   President

 

INVUS PUBLIC EQUITIES ADVISORS, LLC
By:   /s/ Raymond Debbane
Name:   Raymond Debbane
Title:   President

 

ARTAL TREASURY LIMITED
By:   /s/ Kristy Philippe                
Name:   Kristy Philippe
Title:   Director

 

ARTAL INTERNATIONAL S.C.A.
By:   ARTAL INTERNATIONAL MANAGEMENT S.A., its managing partner
By:   /s/ Anne Goffard
Name:   Anne Goffard
Title:   Managing Director

 

ARTAL INTERNATIONAL MANAGEMENT S.A.
By:   /s/ Anne Goffard                
Name:   Anne Goffard
Title:   Managing Director

 

ARTAL GROUP S.A.
By:   /s/ Anne Goffard
Name:   Anne Goffard
Title:   Authorized Person

WESTEND S.A.
By:   /s/ Pascal Minne
Name:   Pascal Minne
Title:   Director

 

STICHTING ADMINISTRATIEKANTOOR WESTEND
By:   /s/ Pascal Minne                
Name:   Pascal Minne
Title:   Sole Member of the Board

 

MR. PASCAL MINNE
/s/ Pascal Minne

Dated: February 12, 2019

EXHIBIT INDEX

 

Exhibit

Number

    Title
1.    Joint Filing Agreement
EXHIBIT 1

EXHIBIT 1

JOINT FILING AGREEMENT

The undersigned agree that the statement on Schedule 13G/A with respect to the common stock, $0.001 par value per share, of ProQR Therapeutics N.V., dated as of February 12, 2019, is, and any amendments thereto signed by each of the undersigned shall be, filed on behalf of each of them pursuant to and in accordance with the provisions of Rule 13d-1(k) under the Securities Exchange Act of 1934, as amended.

 

INVUS PUBLIC EQUITIES, L.P.
By:   INVUS PUBLIC EQUITIES ADVISORS, LLC, its general partner
By:   /s/ Raymond Debbane
Name:   Raymond Debbane
Title:   President

 

INVUS PUBLIC EQUITIES ADVISORS, LLC
By:   /s/ Raymond Debbane
Name:   Raymond Debbane
Title:   President

 

ARTAL TREASURY LIMITED
By:   /s/ Kristy Philippe                
Name:   Kristy Philippe
Title:   Director

 

ARTAL INTERNATIONAL S.C.A.
By:   ARTAL INTERNATIONAL MANAGEMENT S.A., its managing partner
By:   /s/ Anne Goffard
Name:   Anne Goffard
Title:   Managing Director

 

ARTAL INTERNATIONAL MANAGEMENT S.A.
By:   /s/ Anne Goffard                
Name:   Anne Goffard
Title:   Managing Director

ARTAL GROUP S.A.
By:   /s/ Anne Goffard
Name:   Anne Goffard
Title:   Authorized Person

 

WESTEND S.A.
By:   /s/ Pascal Minne
Name:   Pascal Minne
Title:   Director

 

STICHTING ADMINISTRATIEKANTOOR WESTEND
By:   /s/ Pascal Minne                
Name:   Pascal Minne
Title:   Sole Member of the Board

 

MR. PASCAL MINNE
/s/ Pascal Minne

Dated: February 12, 2019